Everything about John Howard Northrop totally explained
John Howard Northrop (
July 5 1891 –
May 27 1987) was an
American biochemist who won the
Nobel Prize in Chemistry in 1946 (with
James Batcheller Sumner and
Wendell Meredith Stanley) for purifying and crystallizing certain enzymes.
Early life
Northrop was born in
Yonkers, New York. His father, a trained
zoologist, died in a lab explosion two weeks before John was born. He was educated at
Columbia University, where he earned his PhD in chemistry in 1915. During
World War I, he conducted research for the U.S. Army Chemical Warfare Service on the production of
acetone and
ethanol through
fermentation. This work led to studying enzymes.
Work
In 1929, he isolated and crystallized the gastric enzyme
pepsin and determined that it was a
protein and in 1938 he isolated and crystallized the first
bacteriophage (a small virus that attacks
bacteria), and determined that it was a
nucleoprotein. Northrop also isolated and crystallized pepsinogen (the precursor to pepsin), trypsin, chymotrypsin, and carboxypeptidase.
His 1939 book,
Crystalline Enzymes, was an important text. Northrop was employed by the
Rockefeller Institute for Medical Research in New York City from 1916 to 1961, at which time he retired. Northrop died in
Wickenburg, Arizona.
His daughter Alice married
Frederick C. Robbins, who was awarded
Nobel Prize in Physiology or Medicine in 1954.
Later life
John Howard Northrop committed suicide
May 27 1987.
Further Information
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